The role of vitamin D deficiency on migraine chronicity has not been clearly identified. The pathogenic mechanism of migraine chronicity presumes to be associated with a neurotransmitter imbalance and upregulation of inflammatory pathways in CNS resulting in central amplification of peripheral pain signals. [ 9]
The present findings show that supplementation with this vitamin in a dose of 1000-4000 IU/d could reduce the frequency of attacks in migraineurs. Conclusion: It seems a high proportion of migraine patients might suffer from vitamin D deficiency/insufficiency.
It seems a high proportion of migraine patients might suffer from vitamin D deficiency/insufficiency. Further, the current evidence shows that in addition to routine drug therapy, vitamin D administration might reduce the frequency of attacks in migraineurs.
Overall, there is not enough evidence to recommend vitamin D supplementation to all headache patients, but the current literature indicates that it may be beneficial in some patients suffering headaches, mainly migraineurs, to reduce the frequency of headaches, especially in those with vitamin D deficiency.
Vitamin D deficiency is associated with chronic pain disorder, depression, and several neurological disorders. 1, 2, 3, 4, 5, 6 The brain has an abundance of vitamin D receptors and there is evidence of a nonskeletal role of vitamin D in inflammation, immunity, and the metabolism of neurotransmitters. 6, 7, 8 In addition, vitamin D has been asso
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vitamin d deficiency and migraines
